The chart-topper delivered a nostalgic trip down memory lane by performing his biggest hits to the 20,000 seater venue.
Despite him only playing for just under an hour, fans of Fiddy were treated to a some of his biggest singles including Candy Shop and In Da Club as well as a host of G-Unit tracks.
One of the biggest crowd pleasers of the night came from his 2007 Justin Timberlake collaboration Ayo Technology.
Taking a detour from his back catalogue, 50 played out Bob Marley’s classic Is This Love before encouraging fans to chill out and ‘smoke weed’.
In a bizarre twist, the chart-topper halted the show to gush over music legend Prince.
“Prince used to do that s***,” he said as a guitarist jammed away next to him.
He continued: “You can do s*** that you couldn’t normally get away with if you play the guitar.
“You know Prince would come out and he would have his ass hanging out of his pants and because he could play the guitar nobody said nothing about that s***
“You know Prince would come out and he would have his ass hanging out of his pants and because he could play the guitar nobody said nothing about that s***”
“I wish I could do that s***… I can’t do that.”
But while his Prince speach may have fallen on deaf ears, his tribute to Grenfell tower certainly hit home.
In respect to the 71 people who lost their lives in the tower block fire last year, the rapper held a minutes silence as he projected a heart covered shrine to Grenfell on big screens around the arena.
An official inquiry into the tragedy is currently ongoing in London.
During a recent hearing, firefighter Norman Harrison begged bosses to abandon the standard ‘stay put’ advice as the blaze ripped through the building.
Mr Harrison said: “I was truly shocked at such a severe fire over so many floors.
“Immediately I knew that stay-put policy should no longer apply in this building… I could see that just didn’t apply here any more.”
Fighting back tears he added: “I think it was a lose-lose situation no matter what decisions were made.
“People were going to die that morning. It was just a matter of how many.”s