Soul singer Aretha Franklin has died at her home in Detroit after a reported eight-year battle with pancreatic cancer aged 76.
The performer, who became the first woman inducted into the Rock and Roll Hall of Fame, was diagnosed with the illness in 2010.
She announced last year she was retiring from music.
Aretha was known for major hits such as Respect and I Say A Little Prayer, and had more than 20 US number ones over the course of her career.
Last year, Aretha gave her last performance at a gala in New York held in aid of the Elton John Aids Foundation.
The music legend began her career as a child, singing gospel at a church in her home state of Michigan.
By the end of the 1960s she had gained the title “Queen of Soul.”
Aretha won 17 Grammy Awards, including six for Best Female R&B Vocal Performance, and three for Best Soul Gospel Performance.
In 1979, she received a star on the Hollywood Walk of Fame and had her voice declared a Michigan “natural resource” in 1985.
Aretha is survived by her four children, Ted White Jr, Kecalf Cunningham, Clarence Franklin and Edward Franklin.
Tributes have poured in for the star online.
Barbara Streisand shared a snap of herself and the singing sensation.
She wrote: “This photo was taken in 2012 when Aretha and I performed at a tribute celebration for our friend Marvin Hamlisch.
“It’s difficult to conceive of a world without her.
“Not only was she a uniquely brilliant singer, but her commitment to civil rights made an indelible impact on the world.”
John Legend added: “Salute to the Queen. The greatest vocalist I’ve ever known.”