The iconic group were due to perform in Boston tonight but pulled the plug hours before being due on stage.
The decision was made after ill heath of one of the band members.
A statement posted on Twitter read: “Due to a band member illness, the Fleetwood Mac show scheduled for tonight, April 2nd, in Boston, Massachusetts will be rescheduled.
“Ticketholders should retain their ticket for the new date which will be announced shortly. Alternately, refunds are available at point of purchase.”
It is not yet know which member of the group has been taken ill or how serious their condition is.
Fleetwood Mac’s tour is set to play a string of dates later this summer.
The group will play two night’s at London’s iconic Wembley Stadium.
It is not known is the rest of the tour will be affected by the mystery illness.
Last wekend Fleetwood Mac played their first of two shows at the 19,000 capacity venue.
A rep for Live Nation, the promotors of Fleetwood Mac’s Tour have been contacted by Daily Star Online for comment.