The US band, consisting of Paul Stanley, Gene Simmons, Eric Singer and Tommy Thayer, released a statement on Friday afternoon to announce that their show at the arena, which was scheduled for 30 May, has been cancelled.
The statement comes as the Manchester Arena has been temporarily closed after 22 people died during a blast at an Ariana Grande concert.
Kiss said: “We are heartbroken by the atrocity committed against the innocent victims of Manchester.
“We sadly will not to be able to play Manchester Arena on the 30th May. We have always looked forward to these shows and our local fans, but in light of recent events a cancelled rock show seems of such little consequence.”
They continued: “Our thoughts and prayers are with the families and friends of those affected and all the people of Manchester at this difficult time.
“We are with you and you are in our prayers.”
It comes after Take That postponed their gigs at the venue, due to take place between Thursday 25-Saturday 27.
Other artists also decided to cancel their concerts on Tuesday, the night after the attack.
Blondie’s Debbie Harry wrote on Twitter: “Out of respect for the victims of the terrible attack at the Manchester Arena last night we will not go ahead with the performance scheduled for this evening at the Round Chapel in Hackney, London.”
Meanwhile Ariana has suspended her world tour following the tragic events.
As well as those killed, 59 were also injured by suicide bomber Salman Ramadan Abedi.
Prime Minister Theresa May has deployed 5,000 soldiers on UK streets as the threat level in the UK is labelled “critical”.Meanwhile Ariana has suspended her world tour following the tragic events.