Perrie Edwards, Jesy Nelson, Jade Thirlwall and Leigh-Anne Pinnock will debut new album LM5 on 16 November.
But they will no longer be working with X Factor boss Simon Cowell after a series of reported rows.
A spokesman for Simon confirmed to the Sun: “Syco Music will no longer work with Modest Management and therefore any artists signed to that management company.
“Syco Music will no longer work with Modest Management and therefore any artists signed to that management company”
Simon Cowell’s spokesman
“We do, of course, wish all artists affected by this decision every future success.
“Consequently, LM5, the forthcoming Little Mix album A&R’d and released on Syco Music, is to be serviced by RCA at the request of Syco and Simon Cowell.”
The Sun reports that the four-piece sent an email direct to Simon, raising their concerns over his label.
Then, it’s said that a row broke out between Little Mix’s management, Modest, and Simon, which saw the two parties cut ties.
Modest Management also have last year’s X Factor champs Rak-Su on their books.
Both Little Mix and Rak-Su are set to move to RCA, which is still part of the Sony group like Syco.
Little Mix bombshell Jesy also liked a post from @littleshadymix on Instagram which read: “They’re gonna leave Syco and then tell us what s*** Syco put them through.”
The girls have been dragged into another argument recently between Nicki Minaj and Cardi B.
Nicki features on their latest single Woman Like Me, however Cardi claimed that she was offered the track first.
Little Mix then shared screenshots of a WhatsApp conversation in which they confirmed that Nicki was approached for the song first.
Nicki also confirmed it, saying: “We all get deals and turn them down. Same with songs.
“Little Mix have been trying to get me on a song for seven years. I finally found one I loved.”